Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents

• 영문명: Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Young Chul Kim Woong Choi Rohyun Sung Heon Kim Ra Young You Seon-Mee Park Sei Jin Youn Mi-Jung Kim Y
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제13권 제6호, 503~510쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2009.01.01

영문 초록

To elucidate the mechanism of cyclic nucleotides, such as adenosine 3 ,5 -cyclic monophosphate (cAMP) and guanosine 3 ,5 -cyclic monophosphate (cGMP), in the regulation of human gastric motility, we examined the effects of forskolin (FSK), isoproterenol (ISO) and sodium nitroprusside (SNP) on the spontaneous, high K^＋ and acetylcholine (ACh)-induced contractions of corporal circular smooth muscle in human stomach. Gastric circular smooth muscle showed regular spontaneous contraction, and FSK, ISO and SNP inhibited its phasic contraction and basal tone in a concentration-dependent manner. High K^＋ (50 mM) produced sustained tonic contraction, and ACh (10ՌM) produced initial transient contraction followed by later sustained tonic contraction with superimposed phasic contractions. FSK, ISO and SNP inhibited high K^＋-induced tonic contraction and also ACh-induced phasic and tonic contraction in a reversible manner. Nifedipine (1ՌM), inhibitor of voltage-dependent L-type calcium current (VDCC_L), almost abolished ACh-induced phasic contractions. These findings suggest that FSK, ISO and SNP, which are known cyclic nucleotide stimulators, inhibit smooth muscle contraction in human stomach partly via inhibition of VDCC_L.

키워드

Gastricintestinal (GI) tract Human stomach Relaxation Forskolin (FSK) Isoproterenol (ISO) Sodium nitorprusside (SNP) Voltage-dependent L-type calcium current (VDCC_L)