Alpha-Calcitonin Gene-Related Peptide-Null Mice Shows Normal Responses to Various Noxious Stimuli

• 영문명: Alpha-Calcitonin Gene-Related Peptide-Null Mice Shows Normal Responses to Various Noxious Stimuli
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Jongho Lee Ronald B. Emeson
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제10권 제6호, 323~328쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2006.01.01

영문 초록

Despite the wealth of data concerning the roles of α-CGRP in nociceptive behaviors, α-CGRP-null mice showed no obvious phenotypic differences in nociceptive behaviors from wild type. The present studies specifically demonstrate that α-CGRP null mice showed no CGRP immunoreactivity from the spinal cord, implying that CGRPs in the mice spinal cord are mainly a-isoforms. However, the nociceptive behaviors of the null mice are not significantly different from the wild type mice in thermal nociceptive behaviors on hotplate, chemical nociception tests to intraplantar capsaicin or formalin injection, and visceral pain behaviors to intraperitoneal acetic acid or magnesium sulfate injections. These data suggest that α-CGRP is dispensable for nociceptive behaviors or that compensatory mechanisms may exist to overcome the absence of this peptide.

키워드

CGRP Pain Knockout mice Spinal cord