Glycyrrhizin and Morroniside Stimulate Mucin Secretion from Cultured Airway Epithelial Cells

• 영문명: Glycyrrhizin and Morroniside Stimulate Mucin Secretion from Cultured Airway Epithelial Cells
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Ho Jin Heo Hyun Jae Lee Cheolsu Kim Kun Ho Son Young Choong Kim Young Sik Kim Sam Sik Kang Yang Chun
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제10권 제6호, 317~322쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2006.01.01

영문 초록

In this study, we investigated whether glycyrrhizin, prunetin and morroniside affect mucin secretion from cultured airway epithelial cells and compared the possible activities of these agents with the inhibitory action on mucin secretion by poly-L-lysine (PLL) and the stimulatory action by adenosine triphosphate (ATP). Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using ³H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on ³H-mucin secretion. The results were as follows: 1) glycyrrhizin and morroniside increased basal mucin secretion from airway; 2) prunetin did not affect basal mucin secretion; 3) glycyrrhizin did not inhibit ATP-induced mucin secretion. We conclude that glycyrrhizin and morroniside can increase basal mucin secretion, by directly acting on airway mucin-secreting cells and suggest that two compounds be further investigated for the possible use as mild expectorants during the treatment of inflammatory airway diseases.

키워드

Airway Mucin Glycyrrhizin and morroniside