Increased Response of Hypogastric Nerve Fibers to Bradykinin by Mustard Oil-Induced Uterine Inflammation in the Rat

• 영문명: Increased Response of Hypogastric Nerve Fibers to Bradykinin by Mustard Oil-Induced Uterine Inflammation in the Rat
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Byeong Kwon Seo Jae Sung Cho Min Goo Lee Seo Eun Lee Hee Chul Han Young Wook Yoon Seung Kil Hong
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제5권 제1호, 99~105쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2001.01.01

영문 초록

It is well known that the inflammation of somatic tissues, bladder and colon can alter the sensitivity of primary afferents innervating these tissues. To see if uterine afferents also show altered sensitivity, we examined their responses to the algesic agent bradykinin before and after induction of uterine inflammation. Inflammation was induced by injecting the mustard oil into the uterine lumen of adult female rats. After induction of inflammation, the response latency to bradykinin did not change, but the duration and peak of the response and integrated impulse discharges during the response period increased significantly. Furthermore, after inflammation, the level of resting discharges of the afferents was much higher. These results are consistent with the idea that the inflammation can sensitize the uterine afferents.

키워드

Bradykinin Inflammation Hypogastric nerve Uterus Mustard oils ANOVA analysis of variance DTT dithiothreitol Grp glucose-regulated protein HSP heat shock family of stress proteins Hsp heat shock protein PDBu phorbol 12,13-dibutyrate