Role of Angiotensin II and Nitric Oxide in the Rat Paraventricular Nucleus
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- 영문명
- Role of Angiotensin II and Nitric Oxide in the Rat Paraventricular Nucleus
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Eun-Kyoung Yang
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제5권 제1호, 41~46쪽, 전체 6쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2001.01.01
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국문 초록
영문 초록
To investigate the mutual relationship between angiotensin II (Ang II) and nitric oxide (NO) in paraventricular nucleus (PVN), Ang II receptor type Ia (AT1A), type Ib (AT1B), endothelial constitutive nitric oxide synthase (ecNOS), and neuronal constitutive nitric oxide synthase (ncNOS) mRNA levels of rat PVN were measured after unilateral carotid artery ligation. AT1A and AT1B mRNA levels were markedly elevated 6 hrs after unilateral carotid artery ligation. Losartan injection (10μg/0.3μl) into the PVN augmented of the increment of AT1A and AT1B mRNAs It also increased ecNOS gene expression. In addition, AT1B mRNA levels increased after N-nitro-L-arginine methyl ester (L-NAME) injection (50μg/0.3μl) into the PVN. These results suggest that Ang II and NO in the rat PVN may interplay, at least in part, through regulation of gene expression of ecNOS and AT1B, respectively.
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