The Effects of Bombesin on the Afferent Sensory Transmission in the Spinal Trigeminal Nucleus of Anesthetized Rats

• 영문명: The Effects of Bombesin on the Afferent Sensory Transmission in the Spinal Trigeminal Nucleus of Anesthetized Rats
• 발행기관: 대한생리학회
• 저자명: Shin, Hyung-Cheul Won, Chung-Kil Kim, Jun Park, Hyoung-Jin
• 간행물 정보: 『대한생리학회지』제28권 제1호, 105~112쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1994.06.30

영문 초록

The present study was carried out to determine the effects of intracisternal administration of three doses of bombesin (0.001, 0.01 and 0.1 μg) on afferent somatosensory transmission in single neurons of the spinal trigeminal nucleus of anesthetized rats. Lower doses (0.001 μg) of bombegin did not change the afferent sensory transmission. Medium doses (0.01 μg) of bombesin significantly (p p<0.01) facilitated afferent sensory transmission in the 6 to 30 min post-drug period, but higher doses (0.1 μg) inhibited responsiveness of spinal trigeminal neurons in the 16 to 35 min post-drug period. The results indicate that endogenous bombesin-like peptide present in the spinal trigeminal nucleus may participate in the processing of the somatosensory information arising from the face.

키워드

Spinal Trigeminal Nucleus Bombesin Afferent Transmission