Facilitation of Afferent Sensory Transmission in the Cuneate Nucleus of Rat during Locomotor Movement

• 영문명: Facilitation of Afferent Sensory Transmission in the Cuneate Nucleus of Rat during Locomotor Movement
• 발행기관: 대한생리학회
• 저자명: Shin, Hyung-Cheul Park, Hyoung-Jin Jin, Byung-Kwan Chapin, John K.
• 간행물 정보: 『대한생리학회지』제28권 제1호, 99~104쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1994.06.30

영문 초록

Single neuronal activities were recorded in the cuneate nucleus of awake rats during rest and running behavior. Movement-induced changes in somatic sensory transmission were tested by generating post-stimulus time histograms of these neurons responses to stimulation through eleetrodes chronically implanted under the skin of the forepaw, during control resting behavior and during two standardized speeds of locomotor movement: slow (1.0 steps/s), fast (2.0 steps/s). The magnitudes of firing during these responses were measured and normalized as percentage increases over background firing. The averaged evoked unit responses were facilitated by +59.3±12.5% and +25.6±5.4% (SEM) as compared with resting behavior, during slow and fast movement respectively. This is to be compared with the movement-induced sensory suppressions observed previously in the ventrobasal thalamus (-31.0%±1.9%) and in the primary somatosensory cortex (-71.2%±3.8%) of slowly running rats. These results suggest that afferent somatosensory information may be uniquely modulated at each sensory relay, such that it may be facilitated at brainstem level and then subjected to suppression at higher somatosensory nuclei during movement.

키워드

Somatosensory Cuneate nucleus Afferent modulation Locomotion