암모니아가 가토심방근 및 동방결절세포의 활동전압에 미치는 효과

• 영문명: Effect of Ammonia on the Action Potential of the Atrial Muscle and Sinus Node Cells of the Rabbit Heart
• 발행기관: 대한생리학회
• 저자명: 조용수(Cho, Yong-Soo) 강석한(Kang, Sok-Han) 김진혁(Kim, Jin-Hyuk) 고상돈(Koh, Sang-Don) 김기순(Kim, Kee-Soon)
• 간행물 정보: 『대한생리학회지』제23권 제2호, 339~350쪽, 전체 12쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1989.12.31

영문 초록

Electrophysiological effects of ammonia was studied in the isolated superfused sinus node and atrial muscle cells of the rabbit heart. No significant changes were observed in the overshoot potential (05), maximum diastolic potential (MDP), and action potential amplitude (APA) of the sinus node cells following superfusion with 3.0 mM ammonia, fifty times upper limit of the normal human plasma level. However the action potential duration (APD) of sinus node cells were significantly prolonged after superfusion with 0.6 mM ammonia for 20 min or with 1.2 and 3.0 mM ammonia for 5 minutes. Ammonia in all the concentrations tested decreased the rate of spontaneous firing (RSF) from the sinus node cells. After superfusion of sinus node cells with 0.3 mM ammonia for 20 min, the RSF significantly decreased from 20 min to 25 min after onset of superfusion while a significant decrement in the RSF was observed from 7 min to 30 min following superfusion with 3.0 mM ammonia for S min. On the other hand, the effects of ammonia on the action potential of the rabbit atrial muscle cell were much similar to those on pacemaker cells except that the atrial cell was generally less sensitive to ammonia. The results suggest that ammonia may cause changes in the action potential of the rabbit cardiac cells by the direct action, and that the cardiac effects of ammonia are generally opposite to those of glycine.

키워드

Ammonia Action potential Sinus node cells Rate of spontaneous firing