기니피그 위점막이 카테콜아민 유발 위운동에 미치는 영향

• 영문명: Influences of Gastric Mucosa upon the Catecholamine Induced Gastric Motility in Guinea-pig
• 발행기관: 대한생리학회
• 저자명: 이풍렬(Rhee, Poong-Lyul) 김기환(Kim, Ki-Whan) 이상진(Lee, Sang-Jin)
• 간행물 정보: 『대한생리학회지』제23권 제2호, 277~290쪽, 전체 14쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1989.12.31

영문 초록

The effects of noradrenaline on the contractile and electrical activities were investigated using the circular muscle strips with intact mucosa prepared from the antrum and fundus of guinea-pig stomach. Electrical responses of circular muscle cells were recorded using glass capillary microelectrodes filled with 3 M KCI. All experiments were performed in tris-buffered Tyrode solution which was aerated with 100% O₂ and kept at 35℃. The results obtained were as follows: 1) The spontaneous contractions recorded from the antral and fundic circular muscle strips with intact mucosa were suppressed dose-dependently by the application of noradrenaline, whereas those recorded from the mucosa-free strips were potentiated in a dose-dependent manner. 2) The inhibitory influences on the contractile activities in the normal intact strips were developed via both α-adrenoceptors and β-adrenoceptors, while the excitatory influences in the mucosa-free strips resulted from the strong excitatory effect via α-adrenoceptors and the weak inhibitory effect via β-adrenoceptors. 3) Noradrenaline produced hyperpolarization of membrane potential, and increased the amplitude and the maximum rate of rise of slow waves in the mucosa-free strips of antral and fundic circular muscle. 4) Apamin blocked the appearance of the component of initial suppression of spontaneous phasic contractions observed in the mucosa-free strips of antral circular muscle after the application of noradrenaline. 5) The inhibitory influences on the contractile activities in the normal strips with intact mucosa remained unaffected even in the strip with separate mucosa, in which mucosa and muscle layer were mechanically disconnected . From the above results, following conclusions could be made. (1) There are no regional differences between the effects of noradrenaline on the antral circular muscle and those on the fundic circular muscle. (2) Excitatory responses to noradrenaline observed in the mucosa-free strip result from the dominant α-excitatory and tile weak β-inhibitory action of noradrenaline. (3) Inhibitory responses to noradrenaline in the normal strips with intact mucosa develop via both α-inhibitory and β-inhibitory actions.

키워드

Antral circular muscle Fundic circular muscle Noradrenaline Slow waves Apamin