가토의 신장기능과 Renin 분비에 미치는 Adenosine수용체 차단제의 영향

• 영문명: Effect of Adenosine Receptor Antagonists on the Renal Function and Renin Release in Rabbits
• 발행기관: 대한생리학회
• 저자명: 이건수(Rhee, Keon-Su) 김영진(Kim, Young-Jin) 김선희(Kim, Suhn-Hee) 조경우(Cho, Kyung-Woo)
• 간행물 정보: 『대한생리학회지』제23권 제2호, 377~392쪽, 전체 16쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1989.12.31

영문 초록

Recently it was suggested that the endogenous adenosine might be the mediator for the intercellular communication in the regulation of tubuloglomerular feedback control and renin release. Even though the previous data showed more important regulatory roles in the renal hemodynamics and renin release for the A1 adenosine receptor, it has not yet been settled down about the functional subclassification of renal adenosine receptors. The purpose of the present experiment was to clarify the importance of the renal adenosine receptors for the regulations of the hemodynamic, excretory and secretory functions. Experiments have been done in unanesthetized rabbits. Intrarenal arterial infusion of A1 adenosine antagonist, 8-phenyltheophylline, 3 ~ 30 nmole/min, increased urine flow, renal hemodynamics and urinary excretion of sodium. Intrarenal arterial infusion of Al antagonist, 1-3-diethyl-8-phenylxanthine (DPX), 10 ~ 100 nmole/min, increased renal hemodynamics and excretory functions. Non-specific adenosine antagonist, theophylline, 30 ~ 300 nmole/min, resulted in dose dependent increases in renal hemodynamics and excretory function. All of the three adenosine antagonists for the increases in renal hemodynamics, excretory and secretory functions was 8-phenyltheophylline > DPX > theophylline. These results suggest that the endogenous adenosine is important for the intrinsic regulatory roles for the renal functions through the adenosine receptors, and that the A1 adenosine receptor is more important than the A2 receptor in the regulation of renal hemodynamics, excretory and renin secretory functions.

키워드

Adenosine antagonist Renin Renal function Rabbit