Higenamine이 단일심근세포의 Ca-전류 및 활동전압에 미치는 효과

• 영문명: Effects of Higenamine on the Calcium Current and the Action Potential in the Guinea-pig Myocytes
• 발행기관: 대한생리학회
• 저자명: 김영덕(Kim, Young-Duck) 서인석(So, In-Suk) 엄융의(Earm, Yung-E)
• 간행물 정보: 『대한생리학회지』제21권 제2호, 169~178쪽, 전체 10쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1987.12.30

영문 초록

The effects of higenamine were investigated in the single atrial and ventricular myocyte of the guinea pig by using patch clamp method. The results obtained were as follows: 1) Isoprenaline which is known to be β-agonist increased the duration of action potential and calcium current in ventricular cells. 2) Higenamine also increased the duration of action potential and calcium current in ventricular myocytes. And its effect was blocked by propranolol. 3) In the atrial cells, isoprenaline showed β-agonist effects, which were increasing the duration of action potential and calcium current same as in ventricular cells. 4) Higenamine, however, showed the opposite effects of β-agonist which were decreasing the duration of action potential and calcium current. The above results suggest that higenamine has the typical β-agonist effect in ventricular cells but inhibitory effect in atrial cells and this effect on atrium could be due to the reduction of calcium current.

키워드

Single atrial and ventricular myocyte Ca-current Isoprenaline Higenamine