생활사건스트레스, 우울증심도와 면역기능

• 영문명: Severity of Stressful Life Events, Depression and Immune Function
• 발행기관: 대한신경정신의학회
• 저자명: 연규월
• 간행물 정보: 『신경정신의학』제36권 제3호, 466~474쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1997.05.30

영문 초록

Objective：Stress and depression have been known to be associated with impairment in immune function. This study was designed to elucidate the abnormalities of humoral immune function in patients with depressive illness. Method：The author compared serum immunoglobulin Ig G, Ig A, Ig M, and complements C3, C4, checked with rate Nephelometry, between hospitalized depressed patients and healthy normal controls. The depressive symptoms were rated with the Hamilton Depression Rating Scale and the current life events were evaluated with the Social Readjustment Rating Scale. Results： 1) Serum levels of immunoglobulin and complements of depressed patients as well as those of normal controls were generally within normal range. 2) The levels of the immunoglobulin Ig M were found to be significantly increased in depressed patients compared to healthy normal controls. 3) The levels of complement C3, C4 tended to be slightly increased in depressed patients compared to healthy normal controls, but with no statistical significance. 4) Serum immunoglobulin and complement levels were not significantly correlated with age, severity of depression and life events in depressed patients. Conclusion：These findings expand previously reported evidence of immune abnormalities in depressive illness and provide a partial explanation for some of these findings and suggest that depressive illness is associated with an acute phase immune response. However, the serum immunoglobulin and complement levels were not correlated with the severity of depression and life events in depressive illness. So, it is difficult to consider the serum immunoglobulin and complement levels as specific markers of depressive illness. Further research on the interaction between hormones and immunity in depression is warranted.

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키워드

Depression Stressful life events Immunoglobulin Complement