Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder

• 발행기관: 대한신경정신의학회
• 저자명: YoungMin Park BunHee Lee HeonJeong Lee SeungGul Kang
• 간행물 정보: 『Psychiatry Investigation』제7권 제3호, 228~230쪽, 전체 3쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.09.30

영문 초록

Duloxetine is a balanced and potent serotonin and noradrenaline reuptake inhibitor (SNRI) and has adverse effects that are commonly associated with such drugs, including nausea, dry mouth, constipation, insomnia, and dizziness. Recently, duloxetine-induced liver injury has also been observed in patients with preexisting liver disease or chronic alcohol use. We investigated the effects of duloxetine in a healthy young adult with major depressive disorder (MDD) but no risk factors, and found that his total bilirubin level increased to 3.3 mg/dL and he developed jaundice after 5 months of duloxetine treatment. Discontinuation of duloxetine treatment saw his total bilirubin level decrease to 1.8 mg/dL. Thus, the administration of duloxetine might induce liver injury in a patient with MDD. However, the limitations of this single case report must be acknowledged. Although the cause of hepatic dysfunction in this case remains to be elucidated, clinicians should monitor liver function carefully after duloxetine treatment. Further investigations with a larger sample are needed.

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INTRODUCTION

CASE

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키워드

Duloxetine Liver injury Hepatic dysfunction Hepatotoxicity Major depressive disorder