학술논문
리스페리돈과 올란자핀을 사용한 정신분열병 환자 치료 패턴의 변이 조사
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- 영문명
- The Variations in the Treatment Pattern of Schizophrenic Patients with Risperidone and Olanzapine
- 발행기관
- 대한신경정신의학회
- 저자명
- 정성훈 안용민 김용식 한국 RODOS 연구자 모임
- 간행물 정보
- 『신경정신의학』제42권 제1호, 79~88쪽, 전체 10쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2003.01.30
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국문 초록
영문 초록
Objectives:Considerable variations in the contents of clinical practice are the natural consequences of the fact that so many factors can have influences on each clinical decision making processes in the psychiatric treatment, let alone the pharmacotherapy of schizophrenia. To attain the goal of rational treatment, it is needed to examine the actual contents of clinical practices
and the degree of variations among diverse hospitals. In addition, it is also needed to look into the unique situations in which each hospital is situated. For this purpose, this study tried to investigate the degree of variations in several aspects of the treatment of schizophrenia with atypical antipsychotics currently practiced in Korea.
Methods:This study is based on the data from RODOS (Risperidone Olanzapine Drug Outcome Study) in Korea. This
study had been designed as a multi-center naturalistic study, therefore, had many advantages for the survey study of actual clinical practices. The subjects of the study were the in-patients who had been given risperidone or olanzapine for the control
of their psychotic symptoms. Clinical data had been gathered by retrospective chart review. The degree and the characteristics of the variations were examined by comparing the patient-characteristic variables and the treatment-related variables among each hospital.
Results:The differences in the baseline characteristics of the patients including the duration of illness and the past history of psychiatric treatment were substantial among each hospital, and these differences seemed to explain a great portion of the variations in the contents of treatment. The variations in the dosage of risperidone and olanzapine were not conspicuous among each hospital. However, the variations in other treatment-related variables, including duration of admission, proportion of combined therapy with other antipsychotics, usage of anticholinergics, detection rate of extrapyramidal symptoms, remained
statistically significant after adjusting the baseline patient characteristics as covariates. Although no significant correlation among each variable was found, a couple of unique practice patterns common to several hospitals could be observed.
Conclusions:Considerable variations in the diverse treatment-related variables were observed in the treatment of schizophrenic patients with risperidone and olanzapine. It seemed that the major portion of these variations could be explained by the characteristic of patient group. However, the possibility remained that the other factors including the socio-cultural environment of the community and the disposition of the clinician themselves were still the major contributing factors to these variations. It is expected that the future clinical practice surveys like this study can help the clinicians to reevaluate their current
practices, and can help to accumulate the basic data needed to establish the more rational and customized treatment practices.
목차
서 론
방 법
결 과
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결 론
REFERENCES
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- 아동 학대 및 방임
- 성폭력
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- 병적 도박의 충동성과 감각추구:알코올중독과의 비교
- 정신분열병에서 특정 증상군에 따른 신경인지 기능의 차이
- 한국어판 강점·난점 설문지(Strengths and Difficulties Questionnaire) 개발
- 청소년기 애착 유형과 부모 양육행동에 관한 연구
- 치매노인의 정신병리와 부양자부담의 연관성
- 치매 선별을 위한 MMSE-K와 K-MMSE의 진단 타당도 비교
- 아동 기질에 대한 부모 설문지”의 한글 표준화 연구(Ⅱ) - 인구통계학적 변인의 탐색 및 규준 수립 -
- 한국인 주요 우울증 환자의 세로토닌 수송체 유전자 다형성과 혈소판 [3H]-세로토닌 흡수양상
- 주의력결핍 과잉행동장애 아동에서 Methylphenidate 투여 전후 [123I]IPT SPECT로 측정한 기저 신경절 Dopamine Transporter Density
- 가정폭력:정신의학의 측면
- 정신의학과 폭력:개요
- 리스페리돈과 올란자핀을 사용한 정신분열병 환자 치료 패턴의 변이 조사
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