학술논문
Chronic Administration of Bacopa Monniera Increases BDNF Protein and mRNA Expressions: A Study in Chronic Unpredictable Stress Induced Animal Model of Depression
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Ritabrata Banerjee Somoday Hazra Anup Kumar Ghosh Amal Chandra Mondal
- 간행물 정보
- 『Psychiatry Investigation』제11권 제3호, 297~306쪽, 전체 10쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2014.07.31
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국문 초록
영문 초록
Objective-The present study aimed to investigate whether graded doses of Bacopa Monniera (BM) extract could produce antidepressant-like effects in chronic unpredictable stress (CUS) induced depression in rats and its possible mechanism(s).
Methods-Rats were subjected to an experimental setting of CUS. The effect of BM extract treatment in CUS-induced depression was examined using behavioral tests including the sucrose consumption, open field test and shuttle box escape test. The mechanism underlying the antidepressant-like action of BM extract was examined by measuring brain-derived neurotrophic factor (BDNF) protein and mRNA expression in brain tissues of CUS-exposed rats.
Results-Exposure to CUS for 4 weeks caused depression-like behavior in rats, as indicated by significant decreases in sucrose consumption, locomotor activity and escape latency. In addition, it was found that BDNF protein and mRNA levels in the hippocampus and frontal cortex were lower in CUS-treated rats, as compared to controls. Daily administration of the graded doses of BM extract during the 4-week period of CUS significantly suppressed behavioral changes and attenuated the CUS-induced decrease in BDNF protein and mRNA levels in the hippocampus and frontal cortex.
Conclusion-The results suggest that BM extract alleviates depression induced by CUS. Present study also confirms that 80–120 mg/kg doses of BM extract have significantly higher antidepressant-like activity.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
키워드
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