학술논문
obIncreased Laterality of the Thalamus in Children and Adolescents with Asperger’s Disorder: An MRI and Proton Spectroscopy Study
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Gokce Nur Say Buyamin Sahin Kerim Aslan Seher Akbas Lutfil Incesu Meltem Ceyhan
- 간행물 정보
- 『Psychiatry Investigation』제11권 제3호, 237~242쪽, 전체 6쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2014.07.31
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국문 초록
영문 초록
Objective-Thalamic abnormalities have been reported in people with pervasive developmental disorders (PDD) including Asperger’s Disorder (ASP). The aim of the present study was to compare the volume and volume fraction of the thalamus and the metabolite concentrations in children and adolescents with ASP using the magnetic resonance imaging and proton magnetic resonance spectroscopy. Additionally, the relationships between thalamic abnormalities and clinical features were examined.
Methods-Volume and volume fractional and metabolic measurements of bilateral thalamus were collected from 15 boys with ASP with a total IQ over 70 (age range 7–18 years, mean age 11.6±3.79 years), and 15 healthy controls matching age, sex and IQ. The thalamic volumes, hemisphere volumes and total brain volumes (TBV) were estimated using the stereological methods on magnetic resonance images. Chemical metabolites of thalamus were evaluated by 1H spectroscopy.
Results-No differences in thalamic volumes, volume fractions and metabolites were observed between the groups. There were significant correlation between thalamic volume and total brain volume in both groups. The ASP group showed a significant left-minus-right thalamus difference as well as a significantly greater laterality index. In addition, a significant correlation between the laterality index and Autism Behavior Checklist language scores was observed.
Conclusion-Findings from this investigation point to a significant increase in laterality of the thalamus and a relationship with language problems in individuals with ASP. Our findings suggest that thalamic abnormalities may be related to mild language problems observed in ASP.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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