저빈도 반복성 경두개 자기자극이 정상인의 시각적 단기 기억에 미치는 영향

• 영문명: Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation on Visual Short Term Memory in Healthy Individuals
• 발행기관: 대한신경정신의학회
• 저자명: 오해정 김원 이경욱 박원명 전태연 한진희 채정호
• 간행물 정보: 『신경정신의학』제43권 제5호, 590~595쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.09.30

영문 초록

Objectives：Repetitive transcranial magnetic stimulation (rTMS) is a novel, noninvasive method of brain stimulation. Since conventional rTMS does not cause seizure, marked advantage over electroconvulsive therapy (ECT), rTMS can be used easily and widely. Once the effects of rTMS on cognitive function are elucidated, its application will be further extended. However, the effects of rTMS on cognitive function have not been well examined. This study aimed to evaluate the effect of low frequency rTMS on visual short term memory. Methods：Forty normal healthy volunteers were randomly assigned to rTMS (n=20) or sham (n=20) groups. The rTMS group were again randomly divided into left prefrontal (n=10) and right prefrontal (n=10) groups. For each group rTMS was given at 1 Hz for 20 minutes with 100% of motor threshold. As a cognitive task, Corsi Block Tapping Test (CORSI) in the computerized Vienna Test System, which can assess visual short term memory, was performed before, during, and after the rTMS. Results：No significant difference was found in the visual short term memories between the rTMS and the sham groups before, during, or after 1 Hz rTMS, nor between the left and right prefrontal rTMS groups. Conclusion：This study demonstrates that rTMS, contrary to ECT, has no adverse visual short term memory effect when used as the standard treatment paradigm. Therefore, rTMS could be a new and safe treatment method in various neuropsychiatric fields without any interference of cognitive function

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키워드

Transcranial magnetic stimulation (TMS) Cognition Visual short-term memory