정신분열병과 Glutathione S-Transferase M1유전자 다형성

• 영문명: Glutathione S-Transferase M1 Polymorphism and Schizophrenia
• 발행기관: 대한신경정신의학회
• 저자명: 배치운 조자현 김연주 김태석 김정진 이창욱 이수정 전태연 이철 백인호
• 간행물 정보: 『신경정신의학』제43권 제5호, 519~523쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.09.30

영문 초록

Objectives：This study aimed to test the possible association between Glutathione S-Transferase M1 gene (GSTM1) variants and schizophrenia. Methods：One hundred and eleven inpatients with schizophrenia and 130 healthy controls were recruited. Genotyping was performed by polymerase chain reaction-based method. Results：The GSTM1 null genotype was significantly more frequent in patients with schizophrenia than in controls (p=0.014, odd ratio=1.93, 95% confidence interval=1.115-3.351), while GSTM1 genotype variants were not associated with either tardive dyskinesia (TD) or total Abnormal Involuntary Movement Scale (AIMS) scores. Conclusion：The present study suggests that the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to TD, at least in Korean population

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키워드

GSTM1 gene polymorphism Schizophrenia Tardive dyskinesia