노인인구에서 대사증후군과 인지기능간의 연관성

• 영문명: Correlation between Metabolic Syndrome and Cognition in the Elderly
• 발행기관: 대한신경정신의학회
• 저자명: 홍창형 김은아 정해관 이동우 차경렬 이강수 오병훈
• 간행물 정보: 『신경정신의학』제45권 제4호, 349~356쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2006.07.30

영문 초록

Objective：The purpose of this study is to find out the effect of ApoE genotype in correlation between metabolic syndrome and cognition of the elderly in the community. Methods：A total of 1,305 subjects (440 men and 865 women) aged 60-98 years were analyzed from preliminary data of Gwangju Dementia and MCI Study (GDEMCIS). The metabolic syndrome was assessed as defined by the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, family history of dementia and stroke, and Korean version-Mini Mental State Examination (K-MMSE). We also examined ApoE genotype and analyzed associated factors with metabolic syndrome. Results：Metabolic syndrome was present in 28.6% of the subjects (13.4% of men and 36.3% of women). On multiple logistic regression analysis, low serum HDL cholesterol was associated with an increased risk for cognitive impairment (KMMSE score≤17) adjusted by age, sex, educational level, and smoking in the presence of ApoE ε4 allele (OR 0.95, 95% CI 0.92-0.99). Conclusion：These results suggest that serum HDL cholesterol may affect cognitive function in the elderly in the presence of ApoE ε4 allele

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키워드

Metabolic syndrome Cognition K-MMSE Elderly ApoE genotype HDL cholesterol