Impaired White Matter Integrity and Social Cognition in High-Function Autism: Diffusion Tensor Imaging Study

• 발행기관: 대한신경정신의학회
• 저자명: WooYoung Im JiHye Ha EunJoo Kim KeunAh Cheon Jaeil Cho DongHo Song
• 간행물 정보: 『Psychiatry Investigation』제15권 제3호, 292~299쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2018.03.31

영문 초록

Objective-It is known that many of the cognitive and social deficits associated with autism can arise from abnormal functional connectivity between brain networks. This aberrant functional connectivity in autism spectrum disorders (ASD) can be explained by impaired integrity of white matter tracts that link distant regions of the networks. Methods-We investigated white matter in 9 children with high-function autism (HFA) compared to 13 typically developing controls using diffusion tensor imaging (DTI). The aim of this research is to provide supporting evidence for abnormalities in neural connectivity as an underlying pathophysiology of the main characteristics of ASD. Results-We found impairment of neural connectivity, mainly in association fiber tracts as evidenced by decreased fractional anisotropy (FA), the index of white matter integrity, of these tracts. Among them, inferior fronto-occipital fasciculus (IFOF) had a significant relationship with ADI-R score. The inferior longitudinal fasciculus (ILF) and superior longitudinal fasciculus (SLF) also showed decreased FA. Decreased FA of ILF and SLF had negative correlations with scores of social interaction. Conclusion-These findings suggest that widespread abnormalities in association fiber tracts may contribute to both core and associated symptoms of ASD.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

키워드

High-function autism Diffusion tensor imaging Brain network Functional connectivity White matter