Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders

• 발행기관: 대한신경정신의학회
• 저자명: Taeyoung Yoo Wonsuk Choi JinHee Hong JuYeon Lee JaeMin Kim IlSeon Shin SooJin Yang Paul Amminger Mic
• 간행물 정보: 『Psychiatry Investigation』제15권 제4호, 396~401쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2018.04.30

영문 초록

Objective-This study examined the association between vitamin D and metabolic syndrome in patients with psychotic disorders. Methods-The study enrolled 302 community-dwelling patients with psychotic disorders. Sociodemographic and clinical characteristics, including blood pressure, physical activity, and dietary habit were gathered. Laboratory examinations included vitamin D, lipid profile, fasting plasma glucose, HbA1c, liver function, and renal function. Vitamin D insufficiency was defined as <20 ng/mL. Clinical characteristics associated with vitamin D insufficiency were identified. Results-Among the 302 participants, 236 patients (78.1%) had a vitamin D insufficiency and 97 (32.1%) had metabolic syndrome. Vitamin D insufficiency was significantly associated with the presence of metabolic syndrome (p=0.006) and hypertension (p=0.017). Significant increases in triglycerides and alanine transaminase were observed in the group with a vitamin D insufficiency (p=0.002 and 0.011, respectively). After adjusting for physical activity and dietary habit scores, vitamin D insufficiency remained significantly associated with metabolic syndrome and hypertension. Conclusion-Vitamin D insufficiency was associated with metabolic syndrome and was particularly associated with high blood pressure, although the nature, direction and implications of this association are unclear.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

키워드

Vitamin D Hypertension Metabolic syndrome Schizophrenia Psychotic disorder