Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder

• 발행기관: 대한신경정신의학회
• 저자명: JunCheng Guo YiJun Yang Min Guo XiaoDan Wang Yang Juan YunSuo Gao LinQiu Fu XiangLing Jiang LinMei F
• 간행물 정보: 『Psychiatry Investigation』제15권 제4호, 407~412쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2018.04.30

영문 초록

Objective-To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). Methods-A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the pvalues were corrected with the permutation test. Results-The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05). Conclusion-The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

키워드

Brain-derived neurotrophic factor Posttraumatic stress disorder Gene polymorphism