암환자 우울증의 약물중재

• 영문명: Evidence Based Pharmacotherapy for Depression in Patients with Cancer
• 발행기관: 대한신경정신의학회
• 저자명: 김정현 함봉진 유은승
• 간행물 정보: 『신경정신의학』제49권 제1호, 37~49쪽, 전체 13쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.01.30

영문 초록

Objectives A significant number of cancer patients experience depressive disorders. Numerous studies have demonstrated that depression in such patients is under-diagnosed and inadequately treated, due to various factors. One of these factors is a lack of an evidence supporting the use of antidepressants in cancer patients. The aim of this systematic review was to establish the evidence for the pharmacological treatment of depression in this population. Methods We searched Korean domestic and international database using the keywords“cancer”,“ depression”, and“pharmacological treatment”, limiting the search to articles published between 1980 and 2008 and grading the reviewed studies’ quality according to Scottish Intercollegiate Guideline Network (SIGN) methodology. Results Of 283 studies searched, 28 studies were appropriate for review. Conclusion The evidence for the pharmacological treatment of depression was limited. However, based on available literature, it seems the newer antidepressants are better tolerated and can be continued safely, with satisfactory efficacy, in cancer patients. Further well-designed, long-term follow-up studies should be conducted.

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REFERENCES

키워드

Cancer Depression Pharmacological treatment