외상성 뇌손상 환자의 SPECT 영상 판독 결과와 통계적 파라미터 지도 분석 결과와의 비교 연구

• 영문명: A Comparison Study between Visual Interpretation and Statistical Parametric Mapping Analysis of Single Photon Emission Computed Tomography Images in Traumatic Brain Injury Patients
• 발행기관: 대한신경정신의학회
• 저자명: 이호선 최준호 김석현 정선녀 최윤영 오동훈
• 간행물 정보: 『신경정신의학』제49권 제5호, 434~443쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.09.30

영문 초록

Objectives The first objective of this study was to examine the extent to which the results of the visual interpretation of brain single photon emission computed tomography (SPECT) images correspond with those of SPM analysis in patients with traumatic brain injury (TBI). The second objective was to explore the possibility of the clinical application of SPM analysis for finding the brain lesions related to the neuropsychiatric symptoms, of which the patients complained. Methods SPECT images from 10 TBI patients (all male, mean age: 46.8±12.32) and 10 age- and sex-matched control subjects were interpreted by an experienced radiologist. Their SPECT images were also analyzed by SPM2 software for comparing the individual images with the controls. Results The results of visual interpretation of SPECT images generally corresponded with those of SPM analysis in five of the 10 TBI cases. In the remaining cases, brain lesions not identified from visual interpretation were found through SPM analysis. The location of these lesions included the anterior cingulate gyrus, caudate nucleus, thalamus, and subcallosal gyrus. SPM analysis also made it easy to find brain hypoperfusion areas associated with the TBI patients’ neuropsychiatric symptoms. Conclusion This study suggested possible clinical applications of SPM analysis of SPECT data from patients with TBI. Its advantages and limitations were discussed.

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키워드

Traumatic brain injury SPECT SPM