팔리페리돈 장기지속형주사제의 약물 순응도와 치료 효과

• 영문명: The Drug Adherence and Treatment Effect of the Paliperidone Long Acting Injection
• 발행기관: 대한신경정신의학회
• 저자명: 김하린 이중선 김창윤 주연호
• 간행물 정보: 『신경정신의학』제54권 제1호, 69~75쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2015.02.28

영문 초록

ObjectivesZZThe aim of this study was to examine the drug adherence and treatment effect of the paliperidone long acting injection (LAI) in patients with schizophrenia or other psychotic disorders. MethodsZZWe reviewed the medical charts of patients who were prescribed paliperidone LAI from January 2010 to April 2014. Date of each injection, last observation, and first admission after use of the drug were obtained. Kaplan-Meier survival analysis was used for calculation of drug adherence. The dose of paliperidone LAI, concurrent oral antipsychotics, and anticholinergic agent was also obtained. Antipsychotics dose was calculated as olanzapine equivalent dose. ResultsZZThe drug adherence of the paliperidone LAI on day 365 was 65%. The reasons for all cause discontinuation were follow-up loss, no effect, poor insight, rejection, extrapyramidal symptom, pain, etc. A total dose of 9.1 mg of oral antipsychotics was decreased, while the dose of anticholinergic agent was increased. ConclusionZZThe drug adherence of the paliperidone LAI was 65%, which was concordant with previous studies. The dose of concurrent oral antipsychotics was increased, while the dose of anticholinergic agent was decreased

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키워드

Schizophrenia Paliperidone palmitate Long acting injection Medication adherence Treatment outcome