학술논문
“Lithium Ion 이 內分泌系臟器에 미치는 影響에 關한 實驗的 研究
이용수 11
- 영문명
- The Effects of Lithium Ion on Endocrine Organs
- 발행기관
- 대한신경정신의학회
- 저자명
- 称 鍵哲
- 간행물 정보
- 『신경정신의학』제7권 제2호, 27~31쪽, 전체 5쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 1968.10.30
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국문 초록
영문 초록
The experimental work was done on white male rats,
weighing between 170gm and 220gm. The experimental
group was divided into A,B,C subgroup. In A and B
subgroup Licl solution in a dose of 2 mEq. per Kg was
injected intraperitoneally for 4 days and 7 days respectively.
In C subgroup Licl in a dose of 1 mEq.
per Kg was injected intraperitoneally for 12 days. The
control group was injected with normal saline intraperitoneally.
In both experimental and control group
100juc of P32 and 7juc of I131 were res pectively injected
on 4th, 7th and 12th day intraperitoneally to a group
of rats. The animals were sacrified 10 hour after the
last injection.
The following results were obtained.
1. The weight of endocrine organ and radioactive
tracer uptake after lithium administration were found
reduced in thymus, testicles and seminal vesicles, whereas
in adrenals these were found increased. In thyroid
I131 uptake was decreased, although P32 uptake was
remarkablley increased.
2. After lithium administration thyroid showed enlarged
follicles, in which profuse thin colloidal substance
was observed. Adrenals showed hypertrophic zona
fasdculata, while the medulla was notablly atrophic.
Subsquent hyperfunction of thyroid and adrenal cortex
were observed.
3. Thymus and seminal vesicles [showed remarkable
atrophy and subsquent hnpofunction of them were
noted.
목차
緖 論
實驗材料 및 方法
實驗 結果
總括 및 考按
結 論
References
키워드
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