알코올 투여가 백서 면역반응 및 종양 발생에 미치는 영향

• 영문명: Effect of Ethanol Administration on Immune Response and Tumorigenesis in Mice
• 발행기관: 대한신경정신의학회
• 저자명: 안영진 은홍배 하대유
• 간행물 정보: 『신경정신의학』제35권 제1호, 163~170쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1996.01.30

영문 초록

For the investigation of the effect of long-term continuous ethanol(EOH) administration and EOH withdrawal on the immune response potential and sexual dimorphism in the tumorigenesis induced by 3-Methylcholanthrene(MCA), the frequency of tumor production and the number of tumors per tumor bearing mouse(TBM) in female and male mice were examined. The production of IL-2 and natural killer cell activity(NKCA) of murine splenocyte were also examined. It was found that EOH feeding may suppress IL-2 production and NKCA but may enhance tumor growth, and there was a sexual dimorphism in tumor production in mice. It was also found that EOH withdrawal decreased the number of tumors per TBM, and EOH termination did not reverse the depression of both IL-2 production and NKCA caused by the previous EOH feeding.

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키워드

Ethanol Immune response Tumorigenesis