急性精神分裂障碍患者의 Haloperidol 治療時 臨床 好轉度와 血中 Prolactin 濃度의 關係

• 영문명: The Relation of Clinical Improvement and Serum Prolactin Levels in the H aloperidol Treatment of Acute Schizophreniform Disorder Patients
• 발행기관: 대한신경정신의학회
• 저자명: 주진형 김성윤 우종인
• 간행물 정보: 『신경정신의학』제35권 제2호, 433~441쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1996.03.30

영문 초록

Objects : The authors investigated to evaluate the clinical utillity of serum prolactin(PRL) level as a therapeutic index of haloperidol treatment for acute psychotic patients. Methods ： 22 patients(10 males, 12 females) first-onset schizophreniform disorder were studied. Among them 10 male patients baseline PRL levels were compared to those of 11 agematched male volunteers and 11 patients who were treated with oral haloperidᄋ1(4 males, 7 females) were studied by measuring baseline and 4the week levels of serum PRL and haloperidol and administering Positive and Negative Syndrome Scale(PANSS) concurrently. Results ： 1) The serum PRL level of 10 male patients showed no statistical difference from 11 healthy males. Only the patients pre-treatment PANSS negative subscale score had significant correlation with the baseline serum PRL level. 2) Percentage of PANSS score change didn’t show significant correlation with the baseline and 4th-week serum PRL level nor with amount and percentage of serum PRL level change. 3) The total PANSS score decreased significantly after 4 week treatment with haloperidol as well as positive symptoms subscale and general psychopathology(all, p 〈 0.05)，and 4th-week serum PRL level significantly increased(p <0.01) compared with the baseline. 4) The 4th-week plasma haloperidol level didn t show correlation with serum PRL level nor with amount and percentage of serum PRL level change. Conclusions : The findings suggest that serum PRL level has limitation for use as therapeutic index of haloperidol treatment for acute psychotic patients.

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키워드

Acute schizophreniform disorder Prolactin Haloperidol