Imipramine의 혈중농도와 심전도 영향

• 영문명: The Plasma Concentrations of Imipramine Hydrochloride and Electrocardiographic Effects
• 발행기관: 대한신경정신의학회
• 저자명: 김시근 허민 김종길
• 간행물 정보: 『신경정신의학』제27권 제5호, 809~816쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1988.09.30

영문 초록

The authors conducted a study on the effects of blood pressure and electrocardiograph of imipramine hydrochloride. Twenty DSM-III diagnosed major depressive patients were administered imipramine orally. The blood pressures were obtained three times during treatment. Although orthostatic hypotension did not produce statistically significant results, it lead to termination of the drug treatment for 1 subject. The standard 12-lead ECG tracing was obtained three times and the plasma concentration was measured two times during treatment. The results on examinations were as follows : 1) Heart rates were increased with plasma imipramine and desmethylimipramine concentrations in the range of 0-50ng/ml, 50-100ng/ml(p<0.01) ， 100-150ng/ml(p

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