Aluminum 이 백서의 뇌중 Choline uptake 및 Choline Acetyltransferase와 Acetylcholinesterase의 활성도에 미치는 효과에 관한 연구

• 영문명: Effects of Aluminum on Choline uptake and Activities of Choline Acetyltransferase and Acetylcholinesterase in Rat Brain
• 발행기관: 대한신경정신의학회
• 저자명: 禹鍾仁 延炳吉 徐維憲 朴贊雄 李定均
• 간행물 정보: 『신경정신의학』제30권 제6호, 961~973쪽, 전체 13쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1991.11.30

영문 초록

The uptake of C3H ) choline into synaptosomes prepared from rat corpus striatum and frontal cortex was studied at choline concentration varying from 0.05 to 2.0 |iM. The sodiumdependent high affinity choline uptake in these brain regions exhibited saturation kinetics with Km values o f 0.37 (iM in corpus striatum and 0.35(iM in frontal cortex. A l3+ inhibited total choline uptake at concentrations greater than 10-4 M. Double-reciprocal plots indicated that A l3+ was a noncompetitive inhibitor o f high affinity choline uptake with Ki values of 2.17X10 3 M in corpus striatum and 0.82 X10 3 M in frontal cortex. The presence of 1 m M Ca2+ neither influenced high affinity choline uptake, nor antagonized the inhibitory effects of A l3+. A l3+ did not alter the activities of choline acetyltransferase and acetylcholinesterase at all substrate and inhibitor concentrations studied. These data suggest that high A l3+ levels modify cholinergic transmission by inhibition of high affinity choline uptake

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