불안장애 환자의 임파구 아형

• 영문명: Lymphocyte Subsets in Anxiety Disorder Patients
• 발행기관: 대한신경정신의학회
• 저자명: 정상교 정영조
• 간행물 정보: 『신경정신의학』제30권 제6호, 951~960쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1991.11.30

영문 초록

The demonstration that behavioral states and CNS processes are associated with immune function suggests that there may be a relationship between anxiety and the immune system. Stress and immunity have been studied extensively, but there have been relatively few studies o f anxiety and immunity. This study was done to study immune function in patients with anxiety disorder focusing on lymphocyte subsets. The subjects were 15 patient with anxiety disorder (5 male, 10 female), 6 with generalized anxiety disorder, 4 with panic disorder, 2 with obsessive compulsive disorder, 2 with post traumatic stress disorder and 1 with phobic disorder diagnosed by three psychiatrists according to DSM-III-R criteria. Their average age was 31 ± 11.4 years. They were admitted to Department of Neuropshcyiatry, Seoul Paik Hospital, from December 1988 to February 1991. The control group were 20 normal healthy adults and 15 hospitalized surgical patients. We measured numbers and ratio o f T cell subsets (including helper- T cells and suppressor-T cells) as well as B cells and total lymphocyte counts in all group. The results were as follows : 1) There were significant differences among patients with anxiety disorder, surgical patients and normal control group in the percentage o f T3, T4, B, and R4/T8 ratio, but no significant differences in number of total lymphocyte, T lymphocyte and percentage of T4. 2) In the each significant group of T3, T4, T4/T8 ratio and B % ； i) The percentage of T8 in patients with anxiety disorder decreased(p

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