생쥐의 강제수영으로 인한 통각둔화 현상에 미치는 P- Chlorphenylalanine과 Naloxone의 효과

• 영문명: Effect of P -Chlorophenylalanine and Naloxone on Forced Swimmirng Induced Analgesia in Mice
• 발행기관: 대한신경정신의학회
• 저자명: 정환증 박제민 김명정
• 간행물 정보: 『신경정신의학』제31권 제5호, 895~908쪽, 전체 14쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1992.09.30

영문 초록

In order to test a hypothesis that the hypoalgesia induced by forced swimming in mice is mediated by central opioid neurons and serotonergic neurons, pain sensitivity was measured by means of tail flick test before and after forced swimming and the effect of naloxone, pchlorophenylalanine( PCTA) and 5-hydroxytryptophan(5HTP) on the change of pain sensitivity was observed to obtain the following results. 1) Pain sensitivity was significantly reduced by forced swimming. 2) Hypoalgesia induced by forced swimming was blocked by naloxone pre treatm ent(2mg/kg). 3) Naloxone pretreatment did not change the pain sensitivity before forced swimming. 4) PCPA pretreatment(300mg/kg once daily for 3days) blocked the hypoalgesic effect induced by forced swimming. 5) PCPA pretreatm ent did not change the pain sensitivity before forced swimming. 6) 5HTP reversed the effect o f PCPA. 7) Large dose (100-200(mg/kg) of 5HTP not only reversed the effect of PCPA, but also reinforced hypoalgesic effect induced by forced swimming. 8) 5HTP pretreatment did not alter the pain sensitivity before forced swimming in PCPA pretreated and control group. From these results it is suggested that the hypoalgesia induced by forced swimming in mice is mediated by activation of endogenous opioid system that requires coaction of 5HT system.

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