慢性精神分裂病 患者에서 電氣衝擊療法이 腦脊髓液 5-HT와 5-HIAA 濃度에 미치는 影響에 관한 研究

• 영문명: The Effect of Electroconvulsive Therapy on the Cerebrospinal Fluid 5-HT and 5-HIAA Concentrations in the Chronic Treatment-Resistant Schizophrenia
• 발행기관: 대한신경정신의학회
• 저자명: 권준수 김기웅 우종인
• 간행물 정보: 『신경정신의학』제31권 제5호, 846~855쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1992.09.30

영문 초록

The effect of a series of ECT treatments on the C SF 5-HT and 5-HIAA concentrations was studied in the 10 patients suffering from chronic treatment-resistant schizophrenia. The clinical improvement of the patients was assessed with BPRS weekly. Total BPRS scores signiflcantiy decreased after a series of ECT treatments. A nd positive, negative, thinking disturbance, withdrawal/retardation and hostility/suspiciousness symptom subscale scores were also decreased significantly after ECT treatments. But anxiety/depression symptom subscale score did not show statistically significant change. The CSF 5-HT concentrations significantly decreased after a series of ECTs. But the CSF 5-HIAA concentrations showed a trend to decrease which was not statistically significant. Percentile improvement on total BPRS score was positively correlated with pre-ECT concentration of CSF 5-HT showed the better clinical improvement. And percentile improvement on total BPRS scores showed significant negative correlation with change in the concentration of 5-HT after ECT treatments. These results suggest that ECT may be effective in the treatm ent of treatment-resistant chomic schizophrenia and, although it’s mechanism is still unknown, may affect the central serotonergic system in schizophrenics, which may be related to the clinical improvement after a series of ECTs.

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키워드

Electroconvulsive therapy (ECT) Chronic schizophrenia 5-HT 5-HIAA CSF Negative symptom