Lithium Carbonate가 白鼠 臀臟에 미치는 影響에 關한 電子顯微鏡的 硏究

• 영문명: Electron Microscopic Study on Rat Kidney Cells after Lithium Carbonate Administration
• 발행기관: 대한신경정신의학회
• 저자명: 이형영 이무석 이귀행 임영진 노승호
• 간행물 정보: 『신경정신의학』제22권 제2호, 187~195쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1983.05.31

영문 초록

To investigate the effects of lith ium carbonate on rat (Sprague-Dawley) kidney cells, light and electron microscopic observation were made. Experimental rats received daily intraperitoneal injections of lithium carbonate in doses of 30 or 150mg/kg. These animals were killed on 6.13. 20. 30 days after the first injection. 1) In the distal convoluted tuble, the 30mg/kg lithium carbonate dosages caused progressive mitochondrial swelling, dilatation of cisternae of rough endoplasmic reticulum, generalized reduction of cell organelles, irregular basal infolding and dilatation of Golgi apparatus. In the proximal tuble, same, dose of lithium carbonate caused appearance of lysosomes, mitochondrial swelling, dilatation of cisternae of rough endoplasmic reticulum, and appearance of dense bodies. These cellular changes were more marked with the lapse of time. 2) In the distal convoluted tuble, the I50mg/kg lithium carbonate dosages produced destruction of basal infolding (which was more severe compared with those 30mg/kg dosage), many vesicles in cytoplasm and cytoplasmic swelling. In the proximal tuble, the same dosages of lithium caused appearance of lysosome, mitochondrial swelling, loss of mitochondrial crest, appearance of many vesicles. These celluar changes were also more marked with the lapse of time. The present study demonstrated th at usual dosage of lithium carbonate do affect the stru-cture of the rat kidney.

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