抗精神病藥物이 血清 Dopamine-b-Hydroxylase 活性度에 미치는 影響

• 영문명: Effect of Antipsychotic Drugs on Serum Dopamine-b Hydroxylase Activity in Chronic Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 薛弦旭 禹鐘仁 李定均
• 간행물 정보: 『신경정신의학』제22권 제2호, 170~179쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1983.05.31

영문 초록

To investigate the effect of antipsychotic drugs directly, the serum dopamine-beta-hydroxylase activ ity was measured before and after three weeks’ washout period in chronic schizophrenics. Total number of subjects were eighty-two chronic schizophrenics, consisting of forty-eight male and thirty-four female patients. The diagnostic criteria was based on DSM-1 and duplicated assay was applied by modified Udenfriend method. The results were as follows; 1. A fter three weeks’ washout period, the serum dopamine-beta-hydroxylase activity was 13. 50 ± 2.12 in male, 11. 72 ±2.12 in female, and 12.76 ±2.30 서m ol/m in/1 in total patients. Serum dopamine-beta-hydroxylase activity of female patients were significantly lower than in male patients. (p<0. 001) 2. The range of serum dopamine-beta-hydroxylase in total patients was from 8.45 to 18.45 umol/ min/1, which is relatively small compared with previous reports in the literature. 3. During the three weeks’ washout period, the percent change was —8.81 ±17.35% in male (p < 0 . 01), 1. 94 ±20. 92% in female (N. S.), and 一4. 35±19. 64% (p<0 . 05) in total patients compare to the serum dopamine-beta-hydroxylase activity of three weeks’ washout period. The difference between male and female ( p < 0. 02) is not clear. 4. D uring the three weeks’ washout period, the absolute value of percent change was 16. 48 ± 10.36% in male, 16. 71 ±13. 93% in female, and 16. 57±11. 40% in total patients, (all, p < 0 . 001) 5. The percent change of serum dopamine-betahydroxylase activity did not seem to be related to the type of drugs, dose of drugs, age, hospital duration, duration of illness, and the presence of active symptom. 6. In summary, the current findings suggest that the interpretation of data indicating low serum dopamine-beta-hydroxylase activity in medica-ted schizophrenics should be made w ith caution

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