Quinupramine의 말초 항 콜린 효과에 관한 연구

• 영문명: A Study on the Peripheral Anticholinergic Effect of Quinupramine
• 발행기관: 대한신경정신의학회
• 저자명: 이종범 김영욱
• 간행물 정보: 『신경정신의학』제30권 제2호, 296~302쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1991.03.30

영문 초록

The authors studied ED 50 of bethanechol on the contractilities of the smooth muscles isolated from various organs of rat under the prescence of atropine (a classical competitive blocker of cholinergic muscarinic receptor), quinupramine(a newly developed antidepressant drug), imipramine and amitriptyline to investigate the peripheral anticholinergic effect o f quinupramine. There was significant difference in the ED 50 of bethanechol between control group and atropine 10 8M group(P〈0.01)，quinupramine 10_7M group(P<0.01)，imipramine 10 7M group(P<0.05) and amitriptyline 10 7M group(P<0.01) in the smooth muscle isolated from duodenum and there was significant difference in the ED 50 of bethanechol between quinupramine 10 7M group and atropine 10 8M group(P<0.05). There was significant difference in the ED 50 of bethanechol between control group and atropine 10 8M group, imipramine 10 7M group and amitriptyline 10 7M group(P<0.01) in the smooth muscle isolated from ascending colon and urinary bladder. But there was no significant difference in the ED 50 of bethanechol between control group and quinupramine 10 7M group in the smooth muscle isolated from ascending colon and urinary bladder

목차

서 론

실험재료 및 방법

실 험 성 적

고 찰

요 약

References

키워드

Quinupramine Anticholinergic effect