전기중격요법후 혈중 Prolactin에 대한 Methysergide의 영향

• 영문명: Effects of Methysergide( Serotonin Antagonist) on Serum Prolactin Response after Electroconvulsive Therapy
• 발행기관: 대한신경정신의학회
• 저자명: 김광수 박원명 이수정 한진희 유태열 방승규
• 간행물 정보: 『신경정신의학』제30권 제2호, 289~295쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1991.03.30

영문 초록

Recently it has been shown in numerous experimental studies that a series of electroconvulsive therapy (ECT) affects neurohormonal function in man, though its mechanism was yet unknown. To investigate effects of methysergide on serum prolactin response after ECT, the authors studied the change of the serum levels of prolactin before ECT (the day before ECT) and after ECT, with and without methysergide pretreatment by RIA method in 11 psychiatric patients. ECT was given with the electrodes placed in the bitemporal position using a pulse current delivering device (Thy matron). The results were as follows ; 1) Compared with the day before ECT, serum prolactin levels were increased significantly at 15，30，60 minutes after ECT(P<0.01). 2) Compared with ECT alone, serum prolactin levels were attenuated significantly at 15，30, 60 minutes after ECT with methysergide (P 〈0.05，P <0.01). Hormonal responses of this study in terms of the knowledge availakle on the neurotransmitter control of prolaetin release suggests that the responses of prolactin to ECT may be mediated by the activation of serotonergic system in central nervous system.

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