학술논문
GABA와 Benzodiazepine 수용체 및 그 기능
이용수 25
- 영문명
- GABA, Benzodiazepine Receptors and Their Functions
- 발행기관
- 대한신경정신의학회
- 저자명
- 정영조 한기석
- 간행물 정보
- 『신경정신의학』제30권 제3호, 431~450쪽, 전체 20쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 1991.05.30
5,200원
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국문 초록
영문 초록
GABA is ubiquitously distributed throughtout the CNS. It is probably the m ajor central
inhibitory am inoacid neurotransm itter which hyperpolarizes the postsynapic neurons and
inhibits the release o f neurotransm itters. G enerally inhibition o f GABA activity causes excitation
leading to anxiety and convulsions, whereas activation of its activity causes antidepressive,
anticonvulsive activity and sedation.
The GABA receptors have been divided into two distinct groups nam ed GABAa and
GABAb receptors by their pharm acological and physiological properties. GABAa
receptors are coupled with Bz binding site and that in conjunction with a C l- channel
they form a supram olecular receptor com plex which m ediates rapid increasing o f C厂 influx
into postsynaptic neurons, thus contributing to the prom pt inhibition of cellular excitability.
O n the contrary, the GABAb receptor does not contain an integral ion channel and
is responsible for slow responses through receptor-G protein-effector complexes, GABAb
receptors appear to be localized on presynaptic nerve term inals and stim ulation o f presynaptic
GABAb receptors reduced C a2+ influx, resulting in decreased release of neurotransmitters.
Stimulation of presynaptic GABAb receptors increases K+ efflux, resulting in inhibition of
cell firing.
A division of function am ong the two types of GABA rceptors appears to e x ist; GABAa
receptor complex mediates anxiety, anticonvulsive acitivty and feeding, GABAb receptors, on
the other hand, are involved in depression and analgesia. In those cases where G A^BAa and
GABAb receptors m ediate similar functions (e.g., cardiovascular regulation), they do so by
affecting different transm itter systems and cellular mechanisms. The putative involvememt
of GABAa and GABAb receptors in various behavioral and physiological effects is sum m arized
in Table 3.
T here are two types of Bz receptors in brain which are central and peripheral type Bz
receptors. Central Bz receptors are in many regions of the brain, coupled with the receptors
for GABA and they mediate the acute actions of Bz in CNS. Although there is general acceptance
that Bz exert their m ajor actions via the GABAa receptors, m ore recent studies suggest
that other systems may be involved.
In addition, endogenous anxiogenic ligands that interact with Bz recrptors in several ways
have been discovered, which of these, P-carbolines and DBI may produce anxiety and convulsion
in human.
The recent investigation of endogenous ligands and specific receptor agonist or antagonist
and inverse agonist provide im portant new conceptual tools for the studies of anxiety, and
depression mechanisms. It is expected that a better understanding of GABA and Bz receptors
will eventually help to dem onstrate the biology of anxiety and depression.
목차
서 론
1. Outline of Neurotransm ission
2. GABA
3. GABAa receptors
4. Benzodiazepine Receptors
5. Endogenous Ligands
6. GABAb Receptors
7. Physiological Effects o f GABA Receptors
요 약
References
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- 여성 물건애 환자 1례
- Benzodiazepine계 약물의 사용과 의존성
- 神經精神醫學에 發表된 論文들의 統計方法의 技術 및 適用 現況
- 지문에 융선해리가 있는 남자 정신분열병 환자의 임상적 특성에 관한 연구
- 정신병환자 가족의 걱정에 관한 조사
- 看護師의 精神科 諮問에 대한 見解
- 한국판 Mini-Mental State Examination(M M SE-K) 상 치매진단이 불확실한 노인들
- 뚜레장애와 인간조직적합성 항원 (HLA)
- 이화방어기제 검사 표준화연구
- 자문조정부서 발족전후 자문의들의 권고에 대한 자문의뢰의들의 일치도의 비교
- 정신분열증 환자의 전산화 단층촬영상 대뇌 비대칭성과 대뇌 위축과의 관계
- Pathways Conducting Cerebellar Evoked Potentials in the Spinal Cord of Rat
- 한국형 알콜 중독 선별검사 제작을 위한 예비연구(III)
- GABA와 Benzodiazepine 수용체 및 그 기능
- 건강염려증 환자의 자아기능에 관한 연구
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