학술논문
Ocular Manifestations of Immune Reconstitution Inflammatory Syndrome in HIV after Highly Active Antiretroviral Therapy: Clinical Use of CD8+ T cell
이용수 0
- 영문명
- 발행기관
- 대한안과학회
- 저자명
- Jae Hyun Kim Myung Ho Cho Ji Hoon Ban Sun Hee Lee Jong Soo Lee
- 간행물 정보
- 『The Korean Journal of Ophthalmology』Vol.39 No.1, 71~79쪽, 전체 9쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2024.12.31
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
Purpose: To investigate ocular manifestation of immune reconstitution inflammatory syndrome (IRIS) in HIV patients after starting highly active antiretroviral therapy (HAART) and its relationship to T cell immunity.
Methods: HIV patients with ocular IRIS after HAART were retrospectively reviewed. Clinical presentations with previous opportunistic infection, duration from initiation of HAART to IRIS, blood CD4+, CD8+ T cell count, and HIV RNA copies before HAART and at IRIS were analyzed.
Results: Among 19 patients (27 eyes) included, the most common previous opportunistic infection was cytomegalovirus (17 patients, 89.5%) followed by tuberculosis choroiditis (2 patients, 10.5%). The clinical manifestations included vitritis (20 eyes, 74.0%), retinitis (14 eyes, 51.9%), and anterior uveitis (5 eyes, 18.5%). The median duration from initiation of HAART to IRIS was 70 days. CD4+ T cell count before HAART increased at IRIS (p < 0.001). CD8+ T cell count before HAART was negatively correlated with duration from HAART to IRIS (p < 0.001). The cutoff value of CD8+ T cell count for discerning early or late onset of ocular IRIS was 258/mm3 (p = 0.001). When divided into two groups by CD8+ T cell count of 258/mm3, 90% patients with CD8+ T cell count higher than 258/mm3 before HAART developed ocular IRIS within 70 days.
Conclusions: There was a negative relationship between CD8+ T cell count before HAART and duration from HAART to ocular IRIS. Ocular IRIS with higher CD8+ T cell count before HAART developed earlier after HAART initiation compared to those with lower CD8+ T cell count.
영문 초록
목차
Materials and Methods
Results
Discussion
References
해당간행물 수록 논문
- Choroidal Neovascularization in a Female Carrier of Ocular Albinism with a GPR143 Mutation: A Case Report
- A Dexamethasone Implant Adherent to Fovea: A Case Report
- Periocular Acupuncture Safety: Concerns Centered on Proper Practice, Not Inherent Acupuncture Risks
- Clinical Outcomes of XEN45 Gel Stent Implantation (Ab Externo, Open Conjunctival Approach) versus Trabeculectomy: A Real-World Study
- Clinical Outcomes and Prognostic Factors in Eyelid Malignancy: A 17-Year Retrospective Analysis of Surgical Management and Reconstruction Techniques
- Ocular Injuries in Patients with Old Blowout Fractures Following Blunt Trauma
- Difference of Parental Level of Concerns on Surgery according to the Perspectives and Characteristic among Pediatrics with Intermittent Exotropia
- Objective Changes in the Contralateral Eye after Unilateral Cataract Surgery
- Primary Sites and Clinicopathological Features of Corneal Melanoma: A Surveillance, Epidemiology, and End Results (SEER) Population-based Study of 29 Cases
- The Effect of Lower Eyelid Blepharoplasty on Corneal Biomechanical Parameters
- Comparison of Toric Intraocular Lens Axis Accuracy between Optical Biometry and Dual Scheimpflug Topography
- Ocular Manifestations of Immune Reconstitution Inflammatory Syndrome in HIV after Highly Active Antiretroviral Therapy: Clinical Use of CD8+ T cell
- Macular Serpiginous Choroidopathy with Secondary Choroidal Neovascularization: A Case Report
- Bilateral Acute Angle-Closure Glaucoma in a Patient with Vogt- Koyanagi-Harada Syndrome: A Case Report
참고문헌
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!