Undaria pinnatifida attenuates DSS-Induced Colitis through Inhibition of NF-κB Activation in Mice

• 발행기관: 한국자원식물학회
• 저자명: Su-Jin Kim
• 간행물 정보: 『한국자원식물학회지』제37권 제6호, 569~575쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

Ulcerative colitis (UC) is a chronic gastrointestinal disorder, the symptoms of which include diarrhea, weight loss, abdominal pain, and intestinal bleeding, resulting in epithelial barrier disruption. Undaria pinnatifida (UP), one of brown algae family, exerts various beneficial biological property including preventing arteriosclerosis and menopausal disorders. This study aims to assess the mechanism by which UP acts a protective effect against dextran sodium sulfate (DSS)-induced colitis in vivo. Mice were divided into four groups : Group I-control group, Group II-DSS alone group, Group III-DSS+ UP (10 ㎎/㎏), Group IV-DSS + UP (100 ㎎/㎏). We evaluated the effects of UP on DSS-induced clinical symptoms by analyzing weight loss and colon length. The regulatory effects of UP on inflammatory mediators were determined in colitis tissue. Results showed that mice UP treatment significantly improved DSS-induced clinical symptoms including weight loss, colon length decrease and diarrhea. Additionally, UP attenuates DSS-induced inflammatory cytokine by blocking nuclear factor-κB (NF-κB) activation in the colons of colitis mice. Collectively, the findings of this study demonstrated the prospect of developing new agents from UP for UC treatment.

목차

Introduction

Materials and Methods

Results

Discussion

Conflicts of Interest

References

키워드

Dextran sulfate sodium Inflammatory cytokine Nuclear factor-κB Ulcerative Colitis Undaria pinnatifida