Jeju Lava Seawater Enhances Anti-inflammatory Activity of Litsea japonica Fruit in LPS-Stimulated RAW 264.7 Cells

• 발행기관: 한국자원식물학회
• 저자명: Boram Go Seon-A Yoon Sung Chun Kim Ho Bong Hyun Hyejin Hyeon So Yeon Oh Young Kyu Lee Ha Jeong Boo Young-Hwan Jung Ki Ju Kim Young-min Ham Weon-Jong Yoon
• 간행물 정보: 『한국자원식물학회지』제37권 제6호, 562~568쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

Litsea japonica fruit has been reported uses to relief bone pain, inflammation, and asthma. In a previous study, we demonstrated that Litsea japonica fruit extract (LFE) exerts anti-inflammatory activity by suppressing NO, iNOS, and COX-2 levels in LPS-stimulated murine macrophage RAW 264.7 cells. This article aimed to address the synergistic effects of Jeju Lava Seawater (JLS) and LFE on anti-inflammatory activity. JLS was optimized to exhibit a Ca:Mg ratio of 2:1 and water hardness of 1,000 ppm. Combined treatment showed stronger inhibition of NO production and iNOS and COX-2 expression compared to the LFE-only treated group. Furthermore, the combined treatment also downregulated the phosphorylation of MAPK/NF-κB and degradation of IκB-α. This investigation indicates that JLS, containing trace elements such as Ca and Mg, would enhance the anti-inflammatory activity of LFE.

목차

Introduction

Materials and Methods

Results

Discussion

Conflicts of Interest

References

키워드

Anti-inflammation Jeju Lava Seawater Litsea japonica fruit RAW 264.7 cells