Parkinson’s Disease Development in Cancer Patients: A population-based nested case-control study

• 발행기관: 대한약학회
• 저자명: Jin Yeon Gil Young Sook Ku Kyung Hyun Min Jun Hyeob Kim Jun Hyuk Park Ji Min Han Kyung Eun Lee
• 간행물 정보: 『약학회지』제68권 제5호(2024년), 371~377쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.10.31

국문 초록

With the increase in cancer survival rates, there is growing interest in the development of progressive neurological disorders such as Parkinson's disease (PD). Thus, we examined the factors associated with the development of PD in cancer patients. In this nested case-control study, we used customized cohort data with PD in Korea from 2010 to 2021 from National Insurance Service system. Among 218,171 cancer patients, 17,338 patients were diagnosed with PD. After 1:1 matching with age and sex, the case and control groups were selected, 11,347 in each group. After adjusting for age, sex, and comorbidities, dementia followed by cerebrovascular disease were significantly associated with PD development. Similar findings were observed in a subgroup of patients with colorectal cancer, where cerebrovascular disease, dementia, and severe liver disease were significantly linked to a higher incidence of PD. Risk factors such as dementia and cerebrovascular disease may play a significant role in patients with cancer for the development of PD.

목차

Introduction

Methods

Results

Discussion

Conclusion

Acknowledgment

Conflict of Interest

References

키워드

Cancer Parkinson’s disease Risk factor Population-based study Claims data