선택적 세로토닌 재흡수 억제제에 의한 망막색소상피세포의 자가포식 유도

• 영문명: Induction of Autophagy by Selective Serotonin Reuptake Inhibitors in Retinal Pigment Epithelial Cells
• 발행기관: 대한약학회
• 저자명: 신채영(Chae Young Shin) 정광원(Kwang Won Jeong)
• 간행물 정보: 『약학회지』제68권 제5호(2024년), 320~324쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.10.31

국문 초록

Dry age-related macular degeneration (AMD) is a disease characterized by the accumulation of drusen in the macula. N-retinylidene-N-retinylethanolamine (A2E) is a representative retinal accumulation product. After photooxidation by blue light in the retina, A2E inhibits autophagy and causes toxicity such as inflammation, lipid peroxidation, destruction of mitochondrial function, and activation of the complement system. Here, we investigated the effect of selective serotonin reuptake inhibitors on autophagy in retinal pigment epithelial cells. Citalopram, fluvoxamine, escitalopram, paroxetine, sertraline, and fluoxetine induced the formation of LC3-II and phosphorylation of p62 in ARPE-19 cells. In addition, these compounds improved autophagic flux monitored by bafilomycin A1 assay. Furthermore, citalopram and fluvoxamine reduced cellular A2E levels in ARPE-19 cells. These results suggest that SSRIs may have the potential to prevent dry AMD, not only by inducing autophagy but also by promoting the removal of A2E in the retina.

목차

서 론(Introduction)

방 법(Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

감사의말씀(Acknowledgment)

Conflict of Interest

References

키워드

Selective serotonin reuptake inhibitors Autophagy Dry AMD Retinal pigment epithelial cells