용융법을 이용한 페북소스타트 고체분산체 개발

• 영문명: Development of Febuxostat Solid Dispersion using a Melting Method
• 발행기관: 대한약학회
• 저자명: 함준식(Jun Sik Ham) 김재선(Jae-Seon Kim) 최진석(Jin-Seok Choi)
• 간행물 정보: 『약학회지』제68권 제4호(2024년), 269~275쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.08.31

국문 초록

Febuxostat is the pH-dependent drug with low solubility in aqueous solution. In the existing method for solubilizing febuxostat, the solvent evaporation method has been widely used, but the melting method is insufficient. The aim of this study is to improve the dissolution percentage of febuxostat and stabilization through Neusilin®UFL2 and D- α-Tocopherol polyethylene glycol 1000 succinate (TPGS) ternary system using a melting method. The optimal formulation (SD1) was developed as a solid dispersion of febuxostat:UFL2®:TPGS=1:3:3 (w/w). The dissolution percentage of SD1 formulation was improved by 1.75 times (in distilled water) and 1.08 times (in pH 6.8 buffer) compared to commercial product (Feburic® tab). Moreover, changes in the physicochemical properties of febuxostat in SD1 formulation were observed (change of meting point, drug-excipients interaction and crystallinity), and it is believed that the dissolution percentage was improved through this. In conclusion, the development of a febuxostat formulation was successful through the melting method, and it is believed that the dissolution percentage was improved by the amorphous febuxostat.

목차

서 론(Introduction)

방 법(Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

감사의말씀(Acknowledgment)

Conflict of Interest

References

키워드

Febuxostat Solid dispersion Melting method Solubilization Dissolution