김치 유래 유산균 포스트바이오틱스 분획물의 대식세포 활성화

• 영문명: Macrophage Activation of Postbiotics Fractions Prepared from Lactic Acid Bacteria Isolated from Kimchi
• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: 정원비(Won Bi Jeong) 김연숙(Yeon Suk Kim) 신현영(Hyun Young Shin) 신지영(Ji-Young Shin) 신광순(Kwang-Soon Shin) 유광원(Kwang-Won Yu)
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』10권 1호, 40~48쪽, 전체 9쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2024.06.30

국문 초록

To suggest the development possibility of immunostimulating materials from lactic acid bacteria (LAB) postbiotics, Lactobacillus sakei/Leuconostoc mesenteroides were isolated from Kimchi. Next, two isolated LAB were cultured to prepare postbiotics (LABP) to measure macrophage activity. LABP significantly increased the production of macrophage stimulating factors such as nitric oxide, tumor necrosis factor-α, and interleukin-6. LABP-crude polysaccharides (CP) fractionated from LABP by EtOH precipitation not only showed more potent macrophage stimulating activity but also induced phagocytic activity in a dose-dependent manner. In addition, LABP-CP was identified as polysaccharides with a major monosaccharide composition of mannose (59.1%), glucose (23.0%), and galactose (14.0%) with high-molecular-weight of 103.5~126.7 kDa. In conclusion, postbiotics prepared from LAB isolated from Kimchi were confirmed to have industrial applications as a functional material with immunostimulating activity.

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키워드

lactic acid bacteria postbiotics Kimchi macrophage activation polysaccharides