Acute Inhalation Toxicity of Butanedioic Acid: A Study in Rats

• 영문명: Acute Inhalation Toxicity of Butanedioic Acid: A Study in Rats
• 발행기관: 한국동물보건학회
• 저자명: Yong-Soon Kim Dae-Sik Rha
• 간행물 정보: 『한국동물보건학회지』3권 2호, 69~75쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.06.30

국문 초록

Butanedioic acid is a water-soluble, colorless to white crystalline powder with no odor and acidic taste. It finds applications in cosmetics, medicine, and industry. Although oral toxicity data is available, inhalation toxicity data remains insufficient for comprehensive hazard assessment. To address this gap, we conducted an acute inhalation toxicity test according to the Organisation for Economic Co-operation and Development guidelines for the testing of chemicals (OECD TG) 436. We used a nose-only inhalation chamber system and a dust generator to expose the rats to test substances for 4 h. The actual (analytical) concentration was 4.878 ± 0.228 mg/L. Clinical signs, mean body weight changes, and gross necropsy results were recorded. No acute toxicity, including death, unusual clinical signs, gross necropsy findings, or abnormal mean body weight changes were observed. Based on these results, we suggest that butanedioic acid does not exhibit acute toxic effects at a concentration of 5 mg/L.

목차

1. Introduction

2. Materials and methods

3. Results

4. Discussion

Acknowledgments

Conflict of Interest

Orcid

References

키워드

Acute inhalation toxicity study Butanedioic acid Aerosol OECD Guideline Sprague-Dawley rat