아밀로이드 양성인 인지기능저하군에서 APOE ε4 유전형이 내측두엽 위축에 미치는 영향

• 영문명: The Effect of Apolipoprotein E ε4 Genotype on the Medial Temporal Lobe Atrophy in Cognitively Impaired Patients With Amyloid Deposition: 2 Years Longitudinal Magnetic Resonance Imaging Study
• 발행기관: 대한노인정신의학회
• 저자명: 김지혜(Jihye Kim) 이영민(Young-Min Lee) 이병대(Byung-Dae Lee) 문은수(Eunsoo Moon) 서화규(Hwagyu Suh) 김경원(Kyungwon Kim) 이현지(Hyunji Lee) 김학진(Hak-Jin Kim) 박경준(Kyongjune Park) 최경운(Kyung-Un Choi)
• 간행물 정보: 『노인정신의학』제28권 제1호, 16~23쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2024.04.30

국문 초록

Objective: Apolipoprotein E (APOE) genotype is associated with risk of Alzheimer’s disease (AD), but the association of APOE ε4 allele with longitudinal medial temporal lobe atrophy (MTA) has been controversial. This study aims to evaluate the effect of APOE genotype on longitudinal MTA over a 2-year period in cognitively impaired patients with amyloid deposition. Methods: This retrospective longitudinal study included 65 cognitively impaired subjects with amyloid deposition (subjective memory impairment, mild cognitive impairment, and mild AD). Participants were divided into carriers (n=27) and non-carriers (n=38) of the ε4 allele. The main outcome is longitudinal reduction of medial temporal lobe (hippocampus, entorhinal cortex, and parahippocampal gyrus) over 2 years. Analysis of covariance was conducted to compare the differences in longitudinal MTA between groups, controlling for covariates. Results: At baseline, hippocampal volume was 4.6% smaller (6.38±1.13 vs. 6.69±0.83, p=0.026) and entorhinal thickness was 6.4% thinner (3.51±0.57 vs. 3.75±0.52, p=0.033) in APOE ε4 carriers than non-carriers. Furthermore, APOE ε4 carriers had significantly 72% greater longitudinal hippocampal atrophy compared to non-carriers (-0.43±0.30 vs. -0.25±0.31, p=0.041). Conclusion: Our findings of baseline or longitudinal MTA in APOE ε4 carriers suggest that APOE ε4 genotype may contribute to underlying pathophysiology of medial temporal lobe in AD.

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키워드

아포지질단백질 E 내측두엽 해마 알츠하이머병 경도인지장애 주관적인지장애 Apolipoproteins E Medial temporal lobe Hippocampus Alzheimer’s disease Mild cognitive impairment Subjective memory impairment