알츠하이머병치매 조기진단 관련 별세포의 역할

• 영문명: The Role of Astrocyte Related to Early Diagnosis of Alzheimer’s Disease Dementia
• 발행기관: 대한노인정신의학회
• 저자명: 추일한(IL Han Choo)
• 간행물 정보: 『노인정신의학』제28권 제1호, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2024.04.30

국문 초록

Astrocyte occupies 20%-40% of all glial cells in human central nervous system (CNS) and is important regulator of CNS inflammatory response. Astrocytes are responsible for controlling neuronal and synaptic homeostasis and playing a critical role in the maintenance of redox status. Reactive astrogliosis, astrocyte remodeling, clasmatodendrosis, and paralysis are related to Alzheimer’s disease dementia (AD). Various astrocyte biomarkers in AD have been applied. Regarding positron emission tomography imaging, radioisotopes such as [11C]-deuterium-L-deprenyl, [18F]-(S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline, [11C]-(2-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-1H-indole) have been proposed for surrogate markers of astrogliosis. There is also now a steadily growing interest in GFAP (glial fibrillary acidic protein) and S100 as cerebrospinal fluid and blood markers. In the future, early intervention related to reactive astrogliosis would make a clue for the early diagnosis and treatment of Alzheimer’s disease.

목차

서 론

별세포의 종류

별세포의 기능

별세포와 노화의 관련성

별세포와 관련된 질환들

AD와 별세포의 연관성

AD의 별세포 생체지표

고 찰

REFERENCES

키워드

별세포 알츠하이머병치매 생체지표 조기진단 Astrocyte Alzheimer’s disease dementia Biomarkers Early diagnosis