국내산 곰취(Ligularia fischen) 추출물의 항염증 활성

• 영문명: Anti-inflammatory Activities of Korean Ligularia Fischeri Extract
• 발행기관: 한국인체미용예술학회
• 저자명: 이해진(Hea-Jin Lee) 임현지(Hyun-Ji Lim) 임미혜(Mi-Hye Lim)
• 간행물 정보: 『한국인체미용예술학회지』제25권 제2호, 155~164쪽, 전체 10쪽
• 주제분류: 예술체육 > 예술일반
• 파일형태: PDF
• 발행일자: 2024.06.20

영문 초록

This study confirmed the anti-inflammatory activities of Ligularia fischeri from Taebaek City, Gangwon-do, using 70% ethanol (LFE). After examining cytotoxicity, the expression values of IL1B, IL6 and TNFA were measured. In addition, the phosphorylation of MAPKinase (ERK, JNK and p38) was analyzed, confirming no significant cytotoxicity in LFE. In LFE 50, 100 and 200 ( / ), both IL1B (0.78±0.10, 0.61±0.10 and ㎍㎖ 0.48±0.19 each) and IL6 (0.63±0.11, 0.54±0.06 and 0.42±0.05 respectively) significantly decreased in terms of gene expression values while TNFA was 0.96±0.08, 0.74±0.08 and 0.71±0.08 each, confirming a significant decrease in 100 / ㎍㎖ or higher levels. In addition, ERK (0.87±0.01, 0.65±0.01 and 0.43±0.01 each) and JNK (0.50±0.16, 0.49±0.17 and 0.48±0.01 respectively) productions decreased accordingly while p38 production was 0.78±0.10, 0.61±0.10 and 0.48±0.19 each in LFE 50, 100 and 200 ( / ), confirming a significant decreas ㎍㎖ e in all levels of concentration. The above results confirmed the anti-inflammatory effects of Ligularia fischeri. It is anticipated that a possibility of Ligularia fischeri as a cosmetic and functional food ingredient could be confirmed through further studies.

목차

Ⅰ. 서론

Ⅱ. 내용 및 방법

Ⅲ. 결과 및 고찰

Ⅳ. 결론

참고문헌

키워드

곰취 항염증 사이토카인 맵카이네즈 천연원료 Ligularia Fischeri Anti-inflammation Cytokine Mitogen-activated Protein Kinase(MAPKinase) Natural Substance