Acrolein과 Acrolein Acetal Form의 합성 및 생물학적 활성에 관한 고찰

• 영문명: Review on the Synthesis and Biological Activities of Acrolein and Its Acetal Form
• 발행기관: 대한약학회
• 저자명: 조은강(Eun Kang Cho) 김예은(Ye Eun Kim) 이상협(Sang Hyup Lee)
• 간행물 정보: 『약학회지』제68권 제1호(2024년), 1~9쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.02.28

영문 초록

Acrolein (2-propenal) is the simplest α,β-unsaturated aldehyde. Humans are exposed to acrolein by smoking, burning woods, oil or fats in meats and vegetables, and by endogenous formation through lipid peroxidation. Acrolein is a highly electrophilic molecule, and readily reacts with nucleophilic biomolecules such as peptides, proteins, and nucleic acids. This high reactivity causes acrolein to have detrimental effects on human or bacteria. The syntheses of acrolein from several starting materials were described. Additionally, several acrolein derivatives and their synthetic process were described with particular emphasis on the acetal forms of acrolein. It is suggested that acrolein and its acetal forms need to be further investigated for medicinal properties.

목차

서론(Introduction)

결론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

Acrolein Acrolein acetal form Aldehyde Antibacterial